Casein expression in cytotoxic T lymphocytes.
نویسندگان
چکیده
منابع مشابه
Cytotoxic T lymphocytes
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are characterized as a small population of cancer cells that have high tumor-initiating ability. CSCs/CICs are resistant to several cancer therapies, and eradication of CSCs/CICs is essential to cure cancer. How can we eradicate CSCs/CICs? Cytotoxic T lymphocytes (CTLs) might be a promising answer.
متن کاملResistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.
To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal antibody to the antigen-specific receptor ...
متن کاملGeneration of Cytotoxic T Lymphocytes in Vitro
Separation of cells by velocity sedimentation at unit gravity was utilized to investigate the physical properties of cytotoxic thymus-derived lymphocytes (CTL) generated in long-term mixed leukocyte cultures (MLC). In kinetic studies, CTL were found almost exclusively in the large cell fractions at the peak of the response on day 4, whereas the majority of CTL in day 14 MLC had the sedimentatio...
متن کاملKilling Mechanisms of Cytotoxic T Lymphocytes.
Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
متن کاملCytotoxic T Lymphocytes and Vaccine Development
Along with the development of new technology, the molecular mechanisms of the generation of functional CTLs have been elucidated over the last several years which together will undoubtedly enhance our progression towards the development of successful vaccines for the many chronic viral infections and cancer. It has been shown that the activation of naı̈ve CTLs requires all three signals to be fu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.17.6897